Oxalyl chloride → 1,4-Dichloro-7-isoquinolinecarbonyl chloride

HRID 2289819ノート

反応式

HRID 2289819 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[Cl:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=C(C(O)=O)[CH:16]=2)[C:11]([Cl:21])=[CH:10][N:9]=1>C(Cl)Cl.CN(C=O)C>[Cl:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:1]([C:2]([Cl:4])=[O:3])[CH:16]=2)[C:11]([Cl:21])=[CH:10][N:9]=1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 186982431,4-Dichloro-7-isoquinolinecarboxylic acid

生成物 1

HCID 186981881,4-Dichloro-7-isoquinolinecarbonyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

Anal. Found: C, 49.59; H, 2.08; N, 5.74. Calc for C10H5Cl2NO2 : C, 49.62; H, 2.08; N, 5.78. ##STR170## Oxalyl chloride (144 μL, 1.65 mmol) was added to a suspension of 1,4-dichloro-7-isoquinolinecarboxylic acid (200 mg, 0.83 mmol) at room temperature in CH2Cl2 (10 mL), followed by DMF (1 drop). After 30 min the resultant clear solution was evaporated in vacuo to afford 1,4-dichloro-7-isoquinolinecarbonyl chloride which was used without further purification.

後処理

  1. customAfter 30 min the resultant clear solution was evaporated in vacuo

出典と根拠

ORDレコード
ord-e008b04eccea4bfc9ff503e33b0eebc9
出典データセット
uspto-grants-2000_07
特許番号
US06093731

反応ノート

読み込み中…