Acetic Anhydride → 7-(Acetylamino)-N-[(4-chlorophenyl)methyl]-4-hydroxy-3-quinolinecarboxamide

HRID 2289913ノート

反応式

HRID 2289913 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:23])=[C:7]([C:12]([NH:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:24](OC(=O)C)(=[O:26])[CH3:25]>N1C=CC=CC=1.O>[C:24]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:23])=[C:7]([C:12]([NH:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)=[O:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1)(=[O:26])[CH3:25]

参加物

5

反応物 2

HCID 7918Acetic Anhydride2 回HCID 178507324HCID 178507324、化合物

生成物 1

HCID 1784740467-(Acetylamino)-N-[(4-chlorophenyl)methyl]-4-hydroxy-3-quinolinecarboxamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1049Pyridine溶媒

実験手順

A solution of 100 mg of 7-amino-N-[(4-chlorophenyl)methyl]-4-hydroxy-3-quinolinecarboxamide in 1 mL of anhydrous pyridine is treated with 0.032 mL of acetic anhydride. After 24 h, an additional 0.005 mL of acetic anhydride is added and the mixture is stirred for an additonal 48 h. The mixture is diluted with 2 mL of distilled water and the precipitate is collected by filtration. It is washed with two 1 mL portions of distilled water and dried in a stream of air. It is dried at 20 torr/75°C./16 h. The product is obtained as 78 mg of a tan solid.

後処理

  1. filtrationthe precipitate is collected by filtration
  2. washIt is washed with two 1 mL portions of distilled water
  3. customdried in a stream of air
  4. customIt is dried at 20 torr/75°C./16 h

出典と根拠

ORDレコード
ord-c4d215c891264b4ebdaf88de5835b42d
出典データセット
uspto-grants-2000_07
特許番号
US06093732

反応ノート

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