p-Toluenesulfonic acid → HCID 178522900、化合物

HRID 2289957ノート

反応式

HRID 2289957 の反応式
[NH2:1][C:2](=[S:26])[C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([F:13])[CH:12]=1)[N:9]=[CH:8][C:7]([C:14]([NH:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)=[O:15])=[C:6]2[OH:25].[C:27]1(C)C=CC(S(O)(=O)=O)=C[CH:28]=1.C(OC(OCC)CBr)C>C(O)(=O)C.C(OCC)(=O)C>[Cl:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][NH:16][C:14]([C:7]2[CH:8]=[N:9][C:10]3[C:5]([C:6]=2[OH:25])=[CH:4][C:3]([C:2]2[S:26][CH:27]=[CH:28][N:1]=2)=[CH:12][C:11]=3[F:13])=[O:15])=[CH:19][CH:20]=1

参加物

6

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 178514136HCID 178514136、化合物

生成物 1

HCID 178522900HCID 178522900、化合物収率 544.9%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
100 °C

実験手順

To a suspension of the title compound of Example 52 (0.14 g) and p-toluenesulfonic acid (0.0084 g) in 2 mL acetic acid is added bromoacetaldehyde diethyl acetal (0.08 mL). The reaction is heated at 100° C. for approximately 45 minutes. The reaction is cooled to room temperature and diluted with 30 mL ethyl acetate. The solid is filtered and dried to give the desired product (0.11 g).

後処理

  1. temperatureThe reaction is cooled to room temperature
  2. filtrationThe solid is filtered
  3. customdried

出典と根拠

ORDレコード
ord-709e3ffad828433a92aa5f1ac4cc2745
出典データセット
uspto-grants-2000_07
特許番号
US06093732

反応ノート

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