反応式
[F:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[Cl:14][C:15]1[CH:25]=[CH:24][C:18]([O:19][CH2:20][CH:21]2[O:23][CH2:22]2)=[CH:17][CH:16]=1>C(O)(C)C>[Cl:14][C:15]1[CH:25]=[CH:24][C:18]([O:19][CH2:20][CH:21]([OH:23])[CH2:22][N:11]2[CH2:10][CH2:9][N:8]([C:3]3[C:2]([F:1])=[CH:7][CH:6]=[CH:5][N:4]=3)[CH2:13][CH2:12]2)=[CH:17][CH:16]=1参加物
4
反応条件
- 温度
- 70 °C
実験手順
To 1-(3-fluoro-2-pyridyl)piperazine (453 mg, 2.5 mmol) in 5 ml of isopropanol stirred under nitrogen at 70° C. was added 4-chlorophenoxy-2,3-epoxypropane (476 mg, 2.5 mmol) portionwise and the solution stirred at 70° C. for 3 hours The solution was concentrated in vacuo and the residual oil chromatographed on silica gel eluting with 5% methanol-chloroform to yield 740 mg (81%) of 1-[3-(4-chlorophenoxy)-2-hydroxypropyl]-4-(3-fluoro-2-pyridyl]piperazine; m.p. 73°-76° C. Analysis satisfactory for C18H21ClFN3O2.
後処理
- concentrationwas concentrated in vacuo
- customthe residual oil chromatographed on silica gel eluting with 5% methanol-chloroform
出典と根拠
- ORDレコード
- ord-fa35163cc57f44ae8a425d1bdca09f5d
- 出典データセット
- uspto-grants-1986_10
- 特許番号
- US04616017
関連ノート
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