4-Chloroaniline → HCID 20232069、化合物

反応式

[CH3:1][C:2]1[N:3]=[C:4](SC)[N:5]=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH:21][C:4]2[N:5]=[N:6][C:7]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[C:2]([CH3:1])[N:3]=2)=[CH:19][CH:18]=1

参加物

反応物 2

HCID 78124-Chloroaniline

HCID 155863425-Methyl-3-methylthio-6-phenyl-1,2,4-triazine

生成物 1

HCID 20232069HCID 20232069、化合物収率 75.2%

実験手順

A mixture of 5-methyl-3-methylthio-6-phenyl-1,2,4-triazine (4.15 g) and p-chloroaniline (4.22 g) was heated at 150° to 160° C. for 18 hours. After cooling, the resulting solid was washed successively with ethyl acetate, chloroform and methanol, and then dried to give 3-(4-chloroanilino)-5-methyl-6-phenyl-1,2,4-triazine (4.26 g).

後処理

temperaturewas heated at 150° to 160° C. for 18 hours
temperatureAfter cooling
washthe resulting solid was washed successively with ethyl acetate, chloroform and methanol
customdried

出典と根拠

ORDレコード: ord-dda4980cc413437c869268617080b1a4
出典データセット: uspto-grants-1986_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04616014

反応ノート

読み込み中…

参加物