Hydrochloric Acid → HCID 20232116、化合物

HRID 2290362ノート

反応式

HRID 2290362 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11]([NH:14][NH2:15])=[N:10][C:9]=2[CH3:16])=[CH:4][CH:3]=1.Cl>C(O)C.[Pd]>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]([CH3:16])[N:10]=[C:11]([NH:14][NH2:15])[NH:12][N:13]=2)=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 20232011HCID 20232011、化合物

生成物 1

HCID 20232116HCID 20232116、化合物収率 80.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

6-(4-Chlorophenyl)-3-hydrazino-5-methyl-1,2,4-triazine (4.36 g) was dissolved in ethanol (70 ml) containing anhydrous hydrogen chloride, and then hydrogenated over 5% palladium on carbon (0.73 g) under atmospheric pressure at room temperature. After the theoretical amount of hydrogen gas was absorbed, the catalyst was filtered off. The filtrate was evaporated under reduced pressure to give a residual solid, which was recrystallized from diluted hydrochloric acid to give colorless crystals of 6-(4-chlorophenyl)-3-hydrazino-5-methyl-2,5-dihydro-1,2,4-triazine hydrochloride (2.04 g), m.p. 207°~208° C.

後処理

  1. customAfter the theoretical amount of hydrogen gas was absorbed
  2. filtrationthe catalyst was filtered off
  3. customThe filtrate was evaporated under reduced pressure
  4. customto give a residual solid, which
  5. customwas recrystallized from diluted hydrochloric acid

出典と根拠

ORDレコード
ord-23e2b66d3e65456a8bdf8578268ebb46
出典データセット
uspto-grants-1986_10
特許番号
US04616014

反応ノート

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