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Potassium Carbonate → Methyl 4-[1-(benzenesulphonyl)-piperazin-4-ylmethyl]-benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| 反応物 | 1-(Benzenesulfonyl)piperazine | HCID 808712 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | Methyl 4-[1-(benzenesulphonyl)-piperazin-4-ylmethyl]-benzoate | HCID 8743532 | — |
反応手順
A mixture of 11.5 g. (50 mmole) methyl 4-bromomethylbenzoate, 11.3 g. (50 mmole) 1-benzenesulphonylpiperazine, 6.91 g. (50 mmole) powdered potassium carbonate and 100 ml. butan-2-one is maintained at reflux temperature for 20 hours, then suction filtered while hot and the filtrate evaporated. After cooling, the product is filtered off with suction and recrystallised from methanol to give 11.6 g. (62% of theory) of the desired product; m.p. 145°-146° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04616086 |
| 出典データセット | uspto-grants-1986_10 |
| ORD ID | ord-3b0bc9d052a841da8602a09a7a0a9eea |
| 出典メモ | uspto-grants-1986_10 |