反应详情

A mixture of 11.5 g. (50 mmole) methyl 4-bromomethylbenzoate, 11.3 g. (50 mmole) 1-benzenesulphonylpiperazine, 6.91 g. (50 mmole) powdered potassium carbonate and 100 ml. butan-2-one is maintained at reflux temperature for 20 hours, then suction filtered while hot and the filtrate evaporated. After cooling, the product is filtered off with suction and recrystallised from methanol to give 11.6 g. (62% of theory) of the desired product; m.p. 145°-146° C.

1. additionA mixture of 11.5 g
2. temperatureat reflux temperature for 20 hours
3. filtrationsuction filtered while hot and the filtrate
4. customevaporated
5. temperatureAfter cooling
6. filtrationthe product is filtered off with suction
7. customrecrystallised from methanol
8. customto give 11.6 g