4-Chlorobenzoyl chloride → Methyl 4-[1-(4-chlorobenzoyl)-piperazin-4-ylmethyl]-benzoate

HRID 2290453

反応式

HRID 2290453 の反応式
[N:1]1([CH2:7][C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>N1C=CC=CC=1>[Cl:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([N:4]2[CH2:5][CH2:6][N:1]([CH2:7][C:8]3[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=3)[CH2:2][CH2:3]2)=[O:24])=[CH:21][CH:20]=1

参加物

4

反応物 2

HCID 85014-Chlorobenzoyl chlorideHCID 7018627Methyl 4-[(piperazin-1-yl)methyl]benzoate

生成物 1

HCID 54279459Methyl 4-[1-(4-chlorobenzoyl)-piperazin-4-ylmethyl]-benzoate

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a solution of 15.3 g. (50 mmole) methyl 4-(piperazin-1-ylmethyl)-benzoate and 175 ml. anhydrous pyridine, there is added dropwise, at 0°-5° C., 8.7 g. (50 mmole) 4-chlorobenzoyl chloride and the reaction mixture kept for a further hour at 0° to 5° C., then overnight at 20° C. The reaction mixture is stirred into ice water and the precipitated product is filtered off with suction, washed with water and dried to give 18.5 g. (quantitative) of the desired product; m.p. 134°-135° C.

後処理

  1. customovernight
  2. customat 20° C
  3. filtrationthe precipitated product is filtered off with suction
  4. washwashed with water
  5. customdried
  6. customto give 18.5 g

出典と根拠

ORDレコード
ord-6dc8888c09b34dc5bb0d689ff177e249
出典データセット
uspto-grants-1986_10
特許番号
US04616086

関連ノート

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