Water → 2-Fluoro-1-(methylsulfonyl)-4-nitrobenzene
反応式
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[CH3:12][S:13]([O-:15])=[O:14].[Na+].O>CS(C)=O>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[S:13]([CH3:12])(=[O:15])=[O:14]参加物
5
反応条件
- 温度
- 60 °C
実験手順
8 g of 3,4-difluoronitrobenzene and 1.01 eq of sodium methanesulfinate (95%) was dissolved in 10 ml of DMSO. The solution was stirred at 60° C. for 3 hours. When the reaction was completed, the solution was added to 100 ml of water to form pale yellow solid, followed by filtration and washing with 50 ml of cool water and 30 ml of n-hexane separately to give 8.8 g of the title compound as a pale yellow solid (yield 79%).
後処理
- customto form pale yellow solid
- filtrationfollowed by filtration
- washwashing with 50 ml of cool water and 30 ml of n-hexane separately
出典と根拠
- ORDレコード
- ord-d65540f051e14807a858c381dcb08832
- 出典データセット
- uspto-grants-2005_02
- 特許番号
- US06849652B1
反応ノート
読み込み中…