Water → 2-Fluoro-1-(methylsulfonyl)-4-nitrobenzene

HRID 22907

反応式

HRID 22907 の反応式
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[CH3:12][S:13]([O-:15])=[O:14].[Na+].O>CS(C)=O>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[S:13]([CH3:12])(=[O:15])=[O:14]

参加物

5

反応物 3

HCID 962WaterHCID 1230531,2-Difluoro-4-nitrobenzeneHCID 2733271Sodium methanesulfinate

生成物 1

HCID 223167812-Fluoro-1-(methylsulfonyl)-4-nitrobenzene収率 79%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
60 °C

実験手順

8 g of 3,4-difluoronitrobenzene and 1.01 eq of sodium methanesulfinate (95%) was dissolved in 10 ml of DMSO. The solution was stirred at 60° C. for 3 hours. When the reaction was completed, the solution was added to 100 ml of water to form pale yellow solid, followed by filtration and washing with 50 ml of cool water and 30 ml of n-hexane separately to give 8.8 g of the title compound as a pale yellow solid (yield 79%).

後処理

  1. customto form pale yellow solid
  2. filtrationfollowed by filtration
  3. washwashing with 50 ml of cool water and 30 ml of n-hexane separately

出典と根拠

ORDレコード
ord-d65540f051e14807a858c381dcb08832
出典データセット
uspto-grants-2005_02
特許番号
US06849652B1

関連ノート

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