反応式
NC(N)=[S:3].[ClH:5].Cl.[Cl:7][C:8]1[CH:25]=[CH:24][C:11]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22]Cl)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1.C(N(CC)CC)C.[OH-].[Na+]>O.C(O)C>[ClH:7].[ClH:5].[Cl:7][C:8]1[CH:25]=[CH:24][C:11]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][SH:3])[CH2:16][CH2:15]2)=[CH:10][CH:9]=1参加物
7
実験手順
The procedure described in Example 1(b) was followed, using 1.3 g of thiourea, 6.4 g of 1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride, 1.6 g of triethylamine and 150 ml of reagent ethanol. The hydrolysis was effected with 3.5 g of sodium hydroxide and 40 ml of water. Work-up, as described above, gave 5.6 g (89% of theory) of 3-[4-(4-chlorophenethyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 279°-281° C.
出典と根拠
- ORDレコード
- ord-e12963865c80428a97701bf8fa770b53
- 出典データセット
- uspto-grants-1986_10
- 特許番号
- US04618677
関連ノート
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