Triethylamine → 3-[4-(3-Phenylpropyl)piperazin-1-yl]propanethiol dihydrochloride

HRID 2290881ノート

反応式

HRID 2290881 の反応式
NC(N)=[S:3].[ClH:5].Cl.[C:7]1([CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][Cl:25])[CH2:18][CH2:17]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C.[OH-].[Na+]>O.C(O)C>[ClH:25].[ClH:5].[C:7]1([CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][SH:3])[CH2:18][CH2:17]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

7

反応物 4

HCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 2723790ThioureaHCID 201531841-(3-Phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride

生成物 1

HCID 137311283-[4-(3-Phenylpropyl)piperazin-1-yl]propanethiol dihydrochloride収率 82%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

The procedure described in Example 1(b) was followed, using 19.0 g of thiourea, 44.0 g of 1-(3-phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride, 25 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 10.0 g of sodium hydroxide in 50 ml of water. Work-up, as described above, gave 35.8 g (82% of theory) of 3-[4-(3-phenylpropyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 237°-239° C.

出典と根拠

ORDレコード
ord-f7ab08950f664f80962854dbf79fa97a
出典データセット
uspto-grants-1986_10
特許番号
US04618677

反応ノート

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