Hydrochloric Acid → 4-(2-Methoxy-5-methylphenyl)-4-oxobutanoic acid

HRID 2290927ノート

反応式

HRID 2290927 の反応式
C([O:3][C:4](=[O:18])[CH2:5][CH2:6][C:7](=[O:17])[C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][C:9]=1[O:15][CH3:16])C.Cl>[OH-].[Na+]>[O:17]=[C:7]([C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][C:9]=1[O:15][CH3:16])[CH2:6][CH2:5][C:4]([OH:18])=[O:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 20230698Ethyl 4-(2-methoxy-5-methylphenyl)-4-oxobutanoate

生成物 1

HCID 2989124-(2-Methoxy-5-methylphenyl)-4-oxobutanoic acid収率 80.6%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of ethyl-4-keto-γ-(2-methoxy-5-methylphenyl)-butyrate (180 g, 0.81 mole) and 1200 mL 20% NaOH was stirred at reflux for 3 hours. After cooling to 0°, the solution was acidified with concentrated HCl. The solid was filtered, washed with water, dried (in-vacuo) to yield 145 g orange solid. Recrystallization from CCl4 yielded 123 g light yellow powder, (68%).

後処理

  1. temperatureat reflux for 3 hours
  2. temperatureAfter cooling to 0°
  3. filtrationThe solid was filtered
  4. washwashed with water
  5. customdried (in-vacuo)

出典と根拠

ORDレコード
ord-06ca8c6bf47243c4bc314b966f46a15f
出典データセット
uspto-grants-1986_10
特許番号
US04618683

反応ノート

読み込み中…