rel-(2R,6S)-2,6-dimethylpiperazine → Sparfloxacin

HRID 2291276

反応式

HRID 2291276 の反応式
[NH2:1][C:2]1[C:11]([F:12])=[C:10](F)[C:9]([F:14])=[C:8]2[C:3]=1[C:4](=[O:21])[C:5]([C:18]([OH:20])=[O:19])=[CH:6][N:7]2[CH:15]1[CH2:17][CH2:16]1.[CH3:22][C@H:23]1[CH2:28][NH:27][CH2:26][C@@H:25]([CH3:29])[NH:24]1>CN(C)C=O>[NH2:1][C:2]1[C:11]([F:12])=[C:10]([N:27]2[CH2:26][C@H:25]([CH3:29])[NH:24][C@H:23]([CH3:22])[CH2:28]2)[C:9]([F:14])=[C:8]2[C:3]=1[C:4](=[O:21])[C:5]([C:18]([OH:20])=[O:19])=[CH:6][N:7]2[CH:15]1[CH2:16][CH2:17]1

参加物

4

反応物 2

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazineHCID 139109475-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

生成物 1

HCID 60464Sparfloxacin

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In the same manner as described in Example 1 (1), a mixture of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, cis-2,6-dimethylpiperazine, and dimethylformamide was stirred at room temperature for 24 hours to give 5-amino-1-cyclopropyl-6,8-difluoro-7-(cis-3,5-dimethyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, m.p. 258°-260° C.

出典と根拠

ORDレコード
ord-1e5b3746ca5e42739940983132139e2b
出典データセット
uspto-grants-1989_01
特許番号
US04795751

関連ノート

読み込み中…