1,1,1-Trifluoro-2-isothiocyanatoethane → HCID 54220720、化合物

HRID 2291334ノート

反応式

HRID 2291334 の反応式
[C:1]([CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[N:10][C:9]([NH2:12])=[N:8]1)#[N:2].[F:13][C:14]([F:20])([F:19])[CH2:15][N:16]=[C:17]=[S:18]>C(#N)C>[F:13][C:14]([F:20])([F:19])[CH2:15][NH:16][C:17](=[S:18])[NH:12][C:9]1[N:10]=[CH:11][N:7]([CH2:6][CH2:5][CH2:4][CH2:3][C:1]#[N:2])[N:8]=1

参加物

4

反応物 2

HCID 138837771,1,1-Trifluoro-2-isothiocyanatoethaneHCID 21279827HCID 21279827、化合物

生成物 1

HCID 54220720HCID 54220720、化合物収率 42.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The crude 1-(4-cyanobutyl)-3-amino-1,2,4-triazole (5.45 g.) in acetonitrile (80 ml.) was treated with 2,2,2-trifluoroethylisothiocyanate (4.4 g.) and the solution heated under reflux for 3.5 hours. Evaporation gave a white sticky solid which was triturated with ether/EtOH to give 5-(3-[3-(2,2,2-trifluoroethyl)thioureido]-1,2,4-triazol-1-yl)valeronitrile (4.04 g.) as a white solid, m.p. 136°-138°.

後処理

  1. temperaturethe solution heated
  2. temperatureunder reflux for 3.5 hours
  3. customEvaporation
  4. customgave a white sticky solid which
  5. customwas triturated with ether/EtOH

出典と根拠

ORDレコード
ord-4714e53a4dc145419b13bb424cd482a9
出典データセット
uspto-grants-1989_01
特許番号
US04795755

反応ノート

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