Hydrochloric Acid → Ethyl 3-(4-methoxy-5-oxo-3-phenyl-2,5-dihydrofuran-2-yl)propanoate

HRID 2291628ノート

反応式

HRID 2291628 の反応式
[OH:1][C:2]1[C:6](=[O:7])[O:5][CH:4]([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[C:3]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[C:21](=O)([O-])[O-].[K+].[K+].CI.Cl>CN(C)C=O>[CH3:21][O:1][C:2]1[C:6](=[O:7])[O:5][CH:4]([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[C:3]=1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 13832246HCID 13832246、化合物

生成物 1

HCID 128354Ethyl 3-(4-methoxy-5-oxo-3-phenyl-2,5-dihydrofuran-2-yl)propanoate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a mixture of ethyl 3-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)propionate (86 g) and potassium carbonate (51.62 g) in N,N-dimethylformamide (855 ml) was added dropwise methyl iodide (23.25 ml) at ambient temperature with stirring and the mixture was stirred for 2.5 hours at the same temperature. The solvent was evaporated in vacuo to give a residue which was poured into diluted hydrochloric acid and extracted with ethyl acetate. The extract was washed with water and brine successively and dried. Evaporation of the solvent gave ethyl 3-(4-methoxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)propionate which was recrystallized from diisopropyl ether (73.07 g).

後処理

  1. stirringthe mixture was stirred for 2.5 hours at the same temperature
  2. customThe solvent was evaporated in vacuo
  3. customto give a residue which
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with water and brine successively
  6. customdried
  7. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-89951bb1a9a640c88d883b96d1989c7a
出典データセット
uspto-grants-1989_01
特許番号
US04797417

反応ノート

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