Hydrochloric Acid → 5-(Trifluoromethyl)isoxazol-3-ylamine

HRID 2291707ノート

反応式

HRID 2291707 の反応式
[F:1][C:2]([F:18])([F:17])[C:3]1[O:7][N:6]=[C:5]([NH:8]C(=O)C2C=CC=CC=2)[CH:4]=1.Cl>C(O)CO>[F:1][C:2]([F:18])([F:17])[C:3]1[O:7][N:6]=[C:5]([NH2:8])[CH:4]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 15613888N-(5-(Trifluoromethyl)isoxazol-3-yl)benzamide

生成物 1

HCID 156138795-(Trifluoromethyl)isoxazol-3-ylamine

試薬・触媒・溶媒 1

HCID 174Ethylene Glycol溶媒

実験手順

The reaction was carried out according to the same procedure as described in Example 50 except that 5-trifluoromethyl-3-benzoylaminoisoxazole (0.8738 g, 3.41 mmole), 36% hydrochloric acid (0.87 g, 8.53 mmole) and ethylene glycol (3.4 ml) were used. The product was then purified by column chromatography on silica gel to give the title compound. Yield: 0.3686 g (75.7%). The structure of this product was confirmed by NMR.

後処理

  1. customThe product was then purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-3ef23fb820734c8d92ba7e00da80f798
出典データセット
uspto-grants-1989_01
特許番号
US04797492

反応ノート

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