Hydrochloric Acid → 5-(Trifluoromethyl)isoxazol-3-ylamine

HRID 2291708ノート

反応式

HRID 2291708 の反応式
[F:1][C:2]([F:16])([F:15])[C:3]1[O:7][N:6]=[C:5]([NH:8]C(=O)C(C)(C)C)[CH:4]=1.Cl>C(O)CO>[F:1][C:2]([F:16])([F:15])[C:3]1[O:7][N:6]=[C:5]([NH2:8])[CH:4]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 156138895-Trifluoromethyl-3-pivaloylaminoisoxazole

生成物 1

HCID 156138795-(Trifluoromethyl)isoxazol-3-ylamine

試薬・触媒・溶媒 1

HCID 174Ethylene Glycol溶媒

実験手順

The reaction was carried out according to the same procedure as described in Example 50 except that 5-trifluoromethyl-3-pivaloylaminoisoxazole (0.7553 g, 3.20 mmole), 36% hydrochloric acid (0.81 g, 8.00 mmole) and ehtylene glycol (3.2 ml) were used. The product was then purified by column chromatography on silica gel to give the title compound. Yield: 0.3686 g (75.7%). The structure of this product was confirmed by NMR.

後処理

  1. customThe product was then purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-9d540287f89c4dd2b760df357577682f
出典データセット
uspto-grants-1989_01
特許番号
US04797492

反応ノート

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