Hydrochloric Acid → 5-(Trifluoromethyl)isoxazol-3-ylamine

HRID 2291709ノート

反応式

HRID 2291709 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[O:7][N:6]=[C:5]([NH:8]C(=O)C)[CH:4]=1.Cl>C(O)CO>[F:1][C:2]([F:13])([F:12])[C:3]1[O:7][N:6]=[C:5]([NH2:8])[CH:4]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 212792665-Trifluoromethyl-3-acetylaminoisoxazole

生成物 1

HCID 156138795-(Trifluoromethyl)isoxazol-3-ylamine

試薬・触媒・溶媒 1

HCID 174Ethylene Glycol溶媒

実験手順

The reaction was carried out according to the same procedure as described in Example 50 except that 5-trifluoromethyl-3-acetylaminoisoxazole (2.21 g, 11.4 mmole), 36% hydrochloric acid (2.89 g, 28.5 mmole) and ehtylene glycol (11.4 ml) were used. The product was then purified by column chromatography on silica gel and further distilled under reduced pressure to give the title compound. Yield: 1.22 g (70.4%), b.p. 84°-85° C./13.0 mmHg.

後処理

  1. customThe product was then purified by column chromatography on silica gel
  2. distillationfurther distilled under reduced pressure

出典と根拠

ORDレコード
ord-b16fdf4684a24f6ca2d8325886bfd4fa
出典データセット
uspto-grants-1989_01
特許番号
US04797492

反応ノート

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