4-Methylmorpholine → N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-O-[(phenylmethoxy)carbonyl]-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide

温度

-20 °C

To N[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide (1.0 g, 2.0 mmol) dissolved in 75 ml of CH2Cl2 and cooled to -20° C. was added 264 mg (0.3 mmol) of N-methylmorpholine. The reaction was then cooled to -78° C. and maintained under an argon atmosphere. Benzylchloroformate (445 mg, 2.5 mmol) was then added to the stirred reaction mixture. The reaction was allowed to slowly warm to room temperature an stir overnight. The mixture was then filtered and the filtrate diluted with CH2CL2 (150 ml). This filtrate was washed 3 times with 75 ml aliquots of 0.5N KHSO4 and once with 75 ml of brine before it was dried over Na2SO4. The organic layer was then stripped of all solvent under reduced pressure to yield a pale yellow solid which by TLC was a mixture of product and starting material. This material was redissolved in 40 ml of CH 2 CL2 and then retreated with N-methylmorpholine and benzylchloroformate in a manner identical to the reaction disclosed above. This second reaction was worked up as described for the original reaction yield a pale yellow solid which was then triterated with hexane containing 5% diethylether to give 1.24 g of the titled product.

1. temperatureThe reaction was then cooled to -78° C.
2. temperaturemaintained under an argon atmosphere
3. temperatureto slowly warm to room temperature an stir overnight
4. filtrationThe mixture was then filtered
5. additionthe filtrate diluted with CH2CL2 (150 ml)
6. washThis filtrate was washed 3 times with 75 ml aliquots of 0.5N KHSO4
7. dry with materialonce with 75 ml of brine before it was dried over Na2SO4
8. customto yield a pale yellow solid which by TLC
9. additiona mixture of product
10. dissolutionThis material was redissolved in 40 ml of CH 2 CL2
11. customThis second reaction
12. customas described for the original reaction
13. customyield a pale yellow solid which

ORDレコード

ord-09ca0d5564694a3582fd19fb698febe1

出典データセット

uspto-grants-1989_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04797470