Hydrochloric Acid → Imazaquin

HRID 2291804

反応式

HRID 2291804 の反応式
[C:1]([C:4]([NH:9][C:10]([C:12]1[C:21]([C:22]([OH:24])=[O:23])=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1)=O)([CH3:8])[CH:5]([CH3:7])[CH3:6])(=[O:3])[NH2:2].[OH-].[Na+].Cl>O>[CH:5]([C:4]1([CH3:8])[C:1](=[O:3])[NH:2][C:10]([C:12]2[C:21]([C:22]([OH:24])=[O:23])=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)=[N:9]1)([CH3:7])[CH3:6]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 134747362-[(1-Carbamoyl-1,2-dimethylpropyl)carbamoyl]-3-quinolinecarboxylic acid

生成物 1

HCID 54739Imazaquin

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 2-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]-3-quinolinecarboxylic acid (0.152 mol), in water (50 ml) containing sodium hydroxide (0.06 mol) is heated at 75° to 80° C. for 2 hours. The solution is cooled in an ice bath and acidified with concentrated hydrochloric acid, added in small increments. The resulting precipitate is filtered, washed with water, air dried, and recrystallized from acetone to afford the 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-quinolinecarboxylic acid, mp 239°-243.5° C.

後処理

  1. temperatureis heated at 75° to 80° C. for 2 hours
  2. temperatureThe solution is cooled in an ice bath
  3. additionadded in small increments
  4. filtrationThe resulting precipitate is filtered
  5. washwashed with water, air
  6. customdried
  7. customrecrystallized from acetone

出典と根拠

ORDレコード
ord-1076902384594129bab1e06e4c600461
出典データセット
uspto-grants-1989_01
特許番号
US04798619

関連ノート

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