Hydrochloric Acid → 1-[5-Hydroxy-2-(phenylethynyl)phenyl]-2-propanone

HRID 2291904ノート

反応式

HRID 2291904 の反応式
C([O:4][C:5]1[CH:6]=[CH:7][C:8]([C:15]#[C:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:9]([CH2:11][C:12](=[O:14])[CH3:13])[CH:10]=1)(=O)C.[OH-].[Na+].Cl>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([C:15]#[C:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[C:9]([CH2:11][C:12](=[O:14])[CH3:13])[CH:10]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 212782901-[5-Acetoxy-2-(phenylethynyl)phenyl]-2-propanone

生成物 1

HCID 212782891-[5-Hydroxy-2-(phenylethynyl)phenyl]-2-propanone収率 101%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1-[5-Acetoxy-2-(phenylethynyl)phenyl]-2-propanone (3.3 g, 11 mmole) was dissolved in MeOH (15 mL) and treated with 50% sodium hydroxide solution (1.8 g, 22 mmole) under argon. The reaction was stirred for 1 hr then poured into dilute hydrochloric acid and extracted with diethyl ether. The combined organic extracts were washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The product was dried under vacuum to yield 2.78 g (98%) of the title compound.

後処理

  1. extractionextracted with diethyl ether
  2. washThe combined organic extracts were washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe product was dried under vacuum

出典と根拠

ORDレコード
ord-d5c60c1579594ad2a2cbc52e098f12ea
出典データセット
uspto-grants-1989_01
特許番号
US04798893

反応ノート

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