Sodium borohydride → 7-Bromo-1,2,3,4-tetrahydro-3,3-dimethyl-1-naphthalenol

HRID 2292041ノート

反応式

HRID 2292041 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][C:7]([CH3:14])([CH3:13])[CH2:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[BH4-].[Na+]>C(O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][C:7]([CH3:14])([CH3:13])[CH2:8][CH:9]2[OH:12])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 157119867-broMo-3,3-diMethyl-3,4-dihydronaphthalen-1(2H)-one

生成物 1

HCID 148194057-Bromo-1,2,3,4-tetrahydro-3,3-dimethyl-1-naphthalenol収率 89%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 7-bromo-3,3-dimethyl-3,4-dihydro-1(2H)-naphthalenone (7.8 g) in dry ethanol (50 ml) at 0° C., was treated with sodium borohydride (1.5 g). The mixture was stirred and allowed to warm to room temperature over 18 hours, and the ethanol removed in vacuo. The residue was partitioned between ethyl acetate and water, and the organic layers were dried and evaporated to give the alcohol as a gum (7.0 g)

後処理

  1. customthe ethanol removed in vacuo
  2. customThe residue was partitioned between ethyl acetate and water
  3. customthe organic layers were dried
  4. customevaporated

出典と根拠

ORDレコード
ord-967ecdb79aab45dca56c6e3262654798
出典データセット
uspto-grants-1989_01
特許番号
US04800212

反応ノート

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