Hydrochloric Acid → 5-Amino-2-chloro-4-fluorophenylthioacetic acid

HRID 2292222ノート

反応式

HRID 2292222 の反応式
C([NH:4][C:5]1[C:6]([F:16])=[CH:7][C:8]([Cl:15])=[C:9]([CH2:11][C:12]([OH:14])=[S:13])[CH:10]=1)(=O)C.Cl.[OH-].[Na+]>>[NH2:4][C:5]1[C:6]([F:16])=[CH:7][C:8]([Cl:15])=[C:9]([CH2:11][C:12]([OH:14])=[S:13])[CH:10]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 1784742305-(N-acetylamino)-2-chloro-4-fluorophenylthioacetic acid

生成物 1

HCID 1785076495-Amino-2-chloro-4-fluorophenylthioacetic acid収率 73%

実験手順

A suspension of 5-(N-acetylamino)-2-chloro-4-fluorophenylthioacetic acid (89.8 g) in a 10% aqueous hydrochloric acid solution was refluxed for 2 hours under heating. After being allowed to cool, an aqueous solution of sodium hydroxide was added to make the suspension at pH 4. After ice-cooling, the precipitated crystals were collected by filteration, washed with ice-water and dried to give 55.0 g of 5-amino-2-chloro-4-fluorophenylthioacetic acid.

後処理

  1. temperaturewas refluxed for 2 hours
  2. temperatureunder heating
  3. temperatureto cool
  4. temperatureAfter ice-cooling
  5. customthe precipitated crystals were collected by filteration
  6. washwashed with ice-water
  7. customdried

出典と根拠

ORDレコード
ord-7f3529986cad486ba39323dd46c4f027
出典データセット
uspto-grants-1989_01
特許番号
US04801408

反応ノート

読み込み中…