4-Acetoxy-3,5-bis[N,N-bis(t-butoxycarbonylmethyl)aminomethyl]-3'-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-beta-methoxycarbonylphenethyl]benzophenone → 3,5-bis[N,N-bis(carboxymethyl)aminomethyl]-4-hydroxy-3'-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-beta-methoxycarbonylphenethyl]benzophenone

HRID 2292323

反応式

HRID 2292323 の反応式
C([O:4][C:5]1[C:42]([CH2:43][N:44]([CH2:53][C:54]([O:56]C(C)(C)C)=[O:55])[CH2:45][C:46]([O:48]C(C)(C)C)=[O:47])=[CH:41][C:8]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][CH:18]([C:37]([O:39][CH3:40])=[O:38])[C:19]3[CH:24]=[C:23]([I:25])[C:22]([O:26][C:27]4[CH:32]=[C:31]([I:33])[C:30]([OH:34])=[C:29]([I:35])[CH:28]=4)=[C:21]([I:36])[CH:20]=3)[CH:12]=2)=[O:10])=[CH:7][C:6]=1[CH2:61][N:62]([CH2:71][C:72]([O:74]C(C)(C)C)=[O:73])[CH2:63][C:64]([O:66]C(C)(C)C)=[O:65])(=O)C>FC(F)(F)C(O)=O.O>[C:64]([CH2:63][N:62]([CH2:61][C:6]1[CH:7]=[C:8]([CH:41]=[C:42]([CH2:43][N:44]([CH2:53][C:54]([OH:56])=[O:55])[CH2:45][C:46]([OH:48])=[O:47])[C:5]=1[OH:4])[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][CH:18]([C:37]([O:39][CH3:40])=[O:38])[C:19]2[CH:24]=[C:23]([I:25])[C:22]([O:26][C:27]3[CH:32]=[C:31]([I:33])[C:30]([OH:34])=[C:29]([I:35])[CH:28]=3)=[C:21]([I:36])[CH:20]=2)[CH:12]=1)=[O:10])[CH2:71][C:72]([OH:74])=[O:73])([OH:66])=[O:65]

参加物

4

反応物 1

HCID 867415754-Acetoxy-3,5-bis[N,N-bis(t-butoxycarbonylmethyl)aminomethyl]-3'-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-beta-methoxycarbonylphenethyl]benzophenone

生成物 1

HCID 538207413,5-bis[N,N-bis(carboxymethyl)aminomethyl]-4-hydroxy-3'-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-beta-methoxycarbonylphenethyl]benzophenone

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 630 mg of 21 in 5 mL of trifluoroacetic acid was stirred overnight, diluted with water and the solid which separated was collected and dried; yield 550 mg. The field desorption mass spectrum showed 22 (m/e1305) is present, as well as some material in which the methyl ester of the thyroxine has been hydrolyzed to the acid.

後処理

  1. customthe solid which separated
  2. customwas collected
  3. customdried

出典と根拠

ORDレコード
ord-8a7b1a651baa4cb6b892f66da1eb9a84
出典データセット
uspto-grants-1989_01
特許番号
US04801722

関連ノート

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