Hexane → 5-Amino-7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran

HRID 2292689ノート

反応式

HRID 2292689 の反応式
[C:1]([C:5]1[C:13]2[O:12][CH2:11][C:10]([CH3:15])([CH3:14])[C:9]=2[CH:8]=[C:7]([N+:16]([O-])=O)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].CCCCCC.CCOC(C)=O>[Pd].CCO>[NH2:16][C:7]1[CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:13]2[O:12][CH2:11][C:10]([CH3:14])([CH3:15])[C:9]=2[CH:8]=1

参加物

6

反応物 3

HCID 8058HexaneHCID 8857Ethyl AcetateHCID 107531427-tert-Butyl-2,3-dihydro-3,3-dimethyl-5-nitro-benzofuran

生成物 1

HCID 106804065-Amino-7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran収率 88.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A suspension of 7-tert-butyl-2,3-dihydro-3,3-dimethyl-5-nitro-benzofuran (2.2 g, 8.8 mmol) and 10% palladium on carbon (200 mg) in absolute EtOH (60 mL) is hydrogenated at 40 psi of H2 pressure on a Parr hydrogenation apparatus for 3 h at 22° C. The reaction is judged complete by TLC (hexane:EtOAc, 19:1; visualized with Dragendorff reagent). The reaction mixture is filtered through Celite and evaporated to yield the title compound as a purple solid (1.7 g, 88%), which is used without further purification.

後処理

  1. filtrationThe reaction mixture is filtered through Celite
  2. customevaporated

出典と根拠

ORDレコード
ord-db63a931f3f943c89666b1b2661fd27f
出典データセット
uspto-grants-1997_11
特許番号
US05684041

反応ノート

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