Trifluoroacetic acid → O-[2-(4-Chlorophenoxy)propyl]hydroxylamine

HRID 2292879ノート

反応式

HRID 2292879 の反応式
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][CH:7]([CH3:14])[CH2:8][O:9][N:10]=C(C)C)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH:7]([CH3:14])[CH2:8][O:9][NH2:10])=[CH:15][CH:16]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 157928292-Propanone, O-[2-(4-chlorophenoxy)propyl]oxime

生成物 1

HCID 15239936O-[2-(4-Chlorophenoxy)propyl]hydroxylamine収率 768.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

10 g (4.13 mmol) of acetone O-[2-(4-chloro-phenoxy)-propyl]-oxime and 31 g of 30% strength aqueous trifluoroacetic acid solution were heated for 83/4 hours at 80° C. at a reduced pressure of 430 mbar, similarly to experiment 3b, 100 g of water being continuously added dropwise to the reaction mixture and a water/acetone mixture being distilled off. The working up similarly to 3b) gave 6.4 g of 2-(4-chlorophenoxy)-propoxyamine in this case. Yield: 76%.

後処理

  1. distillationa water/acetone mixture being distilled off

出典と根拠

ORDレコード
ord-075400f6da3f4b989c956cf76c682acf
出典データセット
uspto-grants-1997_11
特許番号
US05684200

反応ノート

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