Pyridine → 4-Acetoxybiphenyl

HRID 2293008ノート

反応式

HRID 2293008 の反応式
N1C=CC=CC=1.[C:7](Cl)(=[O:9])[CH3:8].[C:11]1([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)Cl>[C:7]([O:23][C:20]1[CH:19]=[CH:18][C:17]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:22][CH:21]=1)(=[O:9])[CH3:8]

参加物

5

反応物 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 71034-Hydroxybiphenyl

生成物 1

HCID 3460664-Acetoxybiphenyl

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
5 °C

実験手順

Pyridine (2 mL) was dissolved in 15 mL of CH2Cl2. The solution was cooled to about 5° C. and stirred while while acetyl chloride (393 mg, 5 mmol) was added slowly. Next, a suspension of p-phenylphenol (0.85 g, 5 mmol) in 20 mL of CH2Cl2 was added dropwise over a 15 min period. The cooling bath was removed and stirring continued for 30 min. The solvents were removed under reduced pressure and 50 mL of ethyl acetate was added to dissolve the solids. The solution was extracted with water, dried over Na2SO4 and evaporated under reduced pressure.

後処理

  1. additionwas added slowly
  2. additionwas added dropwise over a 15 min period
  3. customThe cooling bath was removed
  4. customThe solvents were removed under reduced pressure and 50 mL of ethyl acetate
  5. additionwas added
  6. dissolutionto dissolve the solids
  7. extractionThe solution was extracted with water
  8. dry with materialdried over Na2SO4
  9. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-8ccac658627a42aaa8d79c808775bef1
出典データセット
uspto-grants-1997_11
特許番号
US05686258

反応ノート

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