Phenethylamine → 1-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

反応式

[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:10][C:11]([F:16])([F:15])[C:12](O)=O>>[F:10][C:11]([F:16])([F:15])[CH:12]1[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2][CH2:1][NH:9]1

参加物

反応物 2

HCID 1001Phenethylamine

HCID 6422Trifluoroacetic acid

生成物 1

HCID 214764331-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

実験手順

In accordance with the same procedures as in Preparation 1-1, except that 25 ml of phenethylamine(0.2M) and 30 ml of anhydrous trifluoroacetic acid(0.21M) were used as starting materials, 5.4 g of the title compound was prepared.

後処理

customIn accordance with the same procedures as in Preparation 1-1

出典と根拠

ORDレコード: ord-ab1c1ac0229842e992968e8bb7a17d5b
出典データセット: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05686458

反応ノート

読み込み中…