HCID 86751514、化合物 → HCID 86751513、化合物
反応式
C([N:11]1[CH2:18][CH2:17][CH2:16][C@H:12]1[C:13]([OH:15])=[O:14])(OCC1C=CC=CC=1)=O.[CH2:19]([NH:26][C:27](=[O:34])[C@H:28]([C@H:30]([CH2:32][CH3:33])[CH3:31])[NH2:29])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>[Pd].CO>[NH:11]1[CH2:18][CH2:17][CH2:16][C@H:12]1[C:13]([OH:15])=[O:14].[CH2:19]([NH:26][C:27](=[O:34])[C@H:28]([C@H:30]([CH2:32][CH3:33])[CH3:31])[NH2:29])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1参加物
4
反応条件
- 温度
- 22 °C
実験手順
A solution of N-carbobenzyloxy-L-proline-L-isoleucine benzylamide (36.60 g, 80.95 mmol), 10% palladium on carbon (0.957 g), and methanol (700 mL) was degassed and purged repeatedly (15 times) with hydrogen, and stirred under an atmosphere of hydrogen at 22° C. When TLC analysis indicated the reaction was complete, the solution was purged with argon, filtered through a plug of celite, and concentrated in vacuo to provide 23.71 g, (92%) of L-proline-L-isoleucine benzylamide as a white solid.