Cyclopropyl(3-nitrophenyl)methanone → (3-Aminophenyl)(cyclopropyl)methanone
反応式
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=2)=[O:5])[CH2:3][CH2:2]1.[H][H]>[Pd].CO>[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([NH2:12])[CH:7]=2)=[O:5])[CH2:2][CH2:3]1参加物
5
実験手順
A Parr hydrogenation tube is charged with palladium on carbon (0.030 g). cyclopropyl-(3-nitrophenyl)methanone of Preparation 45 (0.250 g) and 10 mL of methanol. The tube is shaken at room temperature under 40 psi of hydrogen overnight. The reaction mixture is then filtered through Celite and concentrated to give 0.207 g of the title product which is used without further purification.
後処理
- filtrationThe reaction mixture is then filtered through Celite
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-306fdae43ae840b48afe80ec6a50af2d
- 出典データセット
- uspto-grants-1997_11
- 特許番号
- US05686486
反応ノート
読み込み中…