Benzyl Bromide → 4-(Benzyloxy)-2-chloro-1-nitrobenzene

HRID 2293723

反応式

HRID 2293723 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 102833-Chloro-4-nitrophenolHCID 11430Potassium Carbonate

生成物 1

HCID 8198614-(Benzyloxy)-2-chloro-1-nitrobenzene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 3-chloro-4-nitrophenol (10 g, 0.058 mole), benzyl bromide (11.8 g, 0.069 mole), and potassium carbonate (16 g, 0.116 mole) in acetone is stirred, heated at reflux temperature for 17 hours, cooled and filtered. The filtrate is concentrated in vacuo to give a solid residue which is recrystallized from absolute ethanol to give the title compound, mp 82°-84.5° C., identified by elemental and NMR analyses.

後処理

  1. temperatureheated
  2. temperatureat reflux temperature for 17 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. concentrationThe filtrate is concentrated in vacuo
  6. customto give a solid residue which
  7. customis recrystallized from absolute ethanol

出典と根拠

ORDレコード
ord-6c58a18e95044d748314a8edd22ea2ba
出典データセット
uspto-grants-1997_11
特許番号
US05686617

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