Hydrochloric Acid → 5-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride

HRID 2294037

反応式

HRID 2294037 の反応式
[C:1]1([CH3:22])[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[ClH:23]>CO>[ClH:23].[ClH:23].[C:1]1([CH3:22])[CH:2]=[CH:3][C:4]([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:11][CH2:12]2)=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 214736335-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine

生成物 1

HCID 214736325-(4-p-Tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride収率 77%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

0.23 g (0.00077 mol) of 5-(4-p-tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine was dissolved in 220 ml of hot methanol. The solution was treated at room temperature with 0.44 ml (0.00154 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.22 g (77%) of 5-(4-p-tolyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride was obtained as whited crystals; m.p. 220°-222°.

後処理

  1. customthe residue was recrystallized from ethanol/diethyl ether

出典と根拠

ORDレコード
ord-60f3192f14224afc936563c5caeac9ae
出典データセット
uspto-grants-1997_11
特許番号
US05688798

関連ノート

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