Nitric Acid → HCID 21474087、化合物

反応式

[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([C:8](=[O:15])[NH:9][C:10](=[O:14])[NH:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[N+:16]([O-])([OH:18])=[O:17]>>[N+:16]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:4]=1[N+:1]([O-:3])=[O:2])[NH:11][C:10](=[O:14])[NH:9][C:8]2=[O:15])([O-:18])=[O:17]

参加物

反応物 2

HCID 944Nitric Acid

HCID 33981137-Nitroquinazoline-2,4(1H,3H)-dione

生成物 1

HCID 21474087HCID 21474087、化合物収率 59%

実験手順

10 g (48.3 mmol) of 7-nitro-1,2,3,4-tetrahydro-quinazoline-2,4-dione were added portionwise at 0° C. to 32 ml of fuming nitric acid. Thereafter, the mixture was stirred at room temperature for a further 5 hrs. The reaction mixture was poured on to ice, the precipitate was filtered off under suction and washed with 65% nitric acid, dilute nitric acid and finally with water. 7.15 g (59%) of 6,7-dinitro-1,2,3,4-tetrahydroquinazoline-2,4-dione were obtained as a yellow powder;

後処理

additionThe reaction mixture was poured on to ice
filtrationthe precipitate was filtered off under suction
washwashed with 65% nitric acid, dilute nitric acid and finally with water

出典と根拠

ORDレコード: ord-58eac6daefbb4c7581d2368c6af2d754
出典データセット: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05688803

反応ノート

読み込み中…

参加物