HCID 21474355、化合物 → HCID 21474322、化合物
反応式
C([O:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH2:16][CH2:17][OH:18])[C:10]=1[CH:19]([C:21]1[CH:26]=[CH:25][C:24]([O:27]CC2C=CC=CC=2)=[C:23]([O:35][CH3:36])[CH:22]=1)[OH:20])C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH2:16][CH2:17][OH:18])[C:10]=1[CH:19]([OH:20])[C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([O:35][CH3:36])[CH:22]=1参加物
4
実験手順
Under normal pressure and at room temperature, 1.1 g of 3-benzyloxy-2-[(4-benzyloxy-3-methoxy-phenyl)-hydroxy-methyl]-1-(2-hydroxy-ethyl)-1H-pyridin-4-one are hydrogenated in 50 ml of methanol over 0.2 g of palladium on carbon (5%) until 2 mol of H2 per mol of starting material have been taken up. Removal of the catalyst and recrystallisation from ethanol yield 3-hydroxy-1-(2-hydroxy-ethyl)-2-[hydroxy-(4-hydroxy-3-methoxy-phenyl)-methyl]-1H-pyridin-4-one. M.p.: 179°-190° C.