Hydrogen Bromide → 1-(6-Hydroxy-2-naphthalenyl)-1-propanone

HRID 2294276

反応式

HRID 2294276 の反応式
C[O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13](=[O:16])[CH2:14][CH3:15])[CH:9]=2)[CH:4]=1.Br>C(O)(=O)C>[C:13]([C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[CH:4]=[C:3]([OH:2])[CH:12]=[CH:11]2)(=[O:16])[CH2:14][CH3:15]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 759131-(6-Methoxy-2-naphthalenyl)-1-propanone

生成物 1

HCID 214748621-(6-Hydroxy-2-naphthalenyl)-1-propanone収率 56.7%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 10 g of 2-methoxy-6-propionylnaphthalene, prepared according to J. Chem. Soc. (1934), p. 864, in acetic acid (45 ml) and kept under reflux, 47 ml of aqueous HBr (48% by weight) is added during a three-hour time period. The resulting suspension is poured onto 500 g of crushed ice; the formed tars are left in the reaction flask. A suspension is obtained which is filtered on a Buchner filter. The solid material is washed with 100 ml of water, 50 ml of saturated aqueous solution of NaHCO3, and then with 50 ml of water. After drying in air and in oven at 60° C. for 10 hours, 5.3 g of pink-white product is obtained with the following characteristics:

後処理

  1. temperatureunder reflux
  2. waitthe formed tars are left in the reaction flask
  3. customA suspension is obtained which
  4. filtrationis filtered on a Buchner
  5. filtrationfilter
  6. washThe solid material is washed with 100 ml of water, 50 ml of saturated aqueous solution of NaHCO3
  7. customAfter drying in air and in oven at 60° C. for 10 hours

出典と根拠

ORDレコード
ord-e7a1a3b594294f0c9ac18c5194dbfa91
出典データセット
uspto-grants-1997_11
特許番号
US05688846

関連ノート

読み込み中…