Methanol → 3-(N-Methyl-N-phenylamino)-2-hydroxypropylazide
反応式
[CH3:1][N:2]([CH2:9][CH:10]1[CH2:12][O:11]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[N-:13]=[N+:14]=[N-:15].[Na+].C(OC)=O.CO>O>[CH3:1][N:2]([CH2:9][CH:10]([OH:11])[CH2:12][N:13]=[N+:14]=[N-:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1参加物
6
実験手順
A procedure similar to that described in Preparation 12 was repeated, except that 1.65 g of N-methyl-N-phenylaminomethyloxirane (prepared as described in Preparation 88), 3.29 g of sodium azide, 15 ml of methyl formate and 63 ml of an 8:1 by volume mixture of methanol and water were used, to give 1.9 g of the title compound as a pale yellow oil having an Rf value of 0.09 (on silica gel thin layer chromatography, using a 1:15 by volume mixture of ethyl acetate and hexane as the developing solvent).
後処理
- customA procedure similar to that described in Preparation 12
出典と根拠
- ORDレコード
- ord-3d58e28db4964aa0951a694a29c624e7
- 出典データセット
- uspto-grants-1997_11
- 特許番号
- US05688823
反応ノート
読み込み中…