2-Chloro-4-nitrobenzonitrile → 4-Amino-2-chlorobenzonitrile

HRID 2295372

反応式

HRID 2295372 の反応式
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]>O.NN>[Cl:1][C:2]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

参加物

3

反応物 1

HCID 1414012-Chloro-4-nitrobenzonitrile2 回

生成物 1

HCID 887284-Amino-2-chlorobenzonitrile収率 598.3%

試薬・触媒・溶媒 1

HCID 24654Hydrazine hydrate (1:1)溶媒

実験手順

A portion of 2-chloro-4-nitrobenzonitrile (5 g, 0.027 m) was heated with hydrazine monohydrate (110 ml) until the reaction began. Another portion of 2-chloro-4-nitrobenzonitrile (35 g, 0.192 m) was added in predetermined amounts. Once the evolution of nitrogen gas ceased, the reaction mixture was refluxed approximately thirty minutes, and then poured into stirred ice water. The precipitate was filtered and the solid was crystallized from water to yield 2-chloro-4-aminobenzonitrile (25 g, 78%, mp 117° C.).

後処理

  1. temperaturethe reaction mixture was refluxed approximately thirty minutes
  2. additionpoured
  3. filtrationThe precipitate was filtered
  4. customthe solid was crystallized from water

出典と根拠

ORDレコード
ord-00dd216749eb4b8bb83edd99435101ce
出典データセット
uspto-grants-1984_01
特許番号
US04424371

関連ノート

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