2-Chloro-4-nitrobenzonitrile → 4-Amino-2-chlorobenzonitrile
反応式
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]>O.NN>[Cl:1][C:2]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]参加物
3
実験手順
A portion of 2-chloro-4-nitrobenzonitrile (5 g, 0.027 m) was heated with hydrazine monohydrate (110 ml) until the reaction began. Another portion of 2-chloro-4-nitrobenzonitrile (35 g, 0.192 m) was added in predetermined amounts. Once the evolution of nitrogen gas ceased, the reaction mixture was refluxed approximately thirty minutes, and then poured into stirred ice water. The precipitate was filtered and the solid was crystallized from water to yield 2-chloro-4-aminobenzonitrile (25 g, 78%, mp 117° C.).
後処理
- temperaturethe reaction mixture was refluxed approximately thirty minutes
- additionpoured
- filtrationThe precipitate was filtered
- customthe solid was crystallized from water
出典と根拠
- ORDレコード
- ord-00dd216749eb4b8bb83edd99435101ce
- 出典データセット
- uspto-grants-1984_01
- 特許番号
- US04424371
反応ノート
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