Hydrochloric Acid → 1-(Cyclohexylmethyl)piperazine hydrochloride

HRID 22954

反応式

HRID 22954 の反応式
C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C(N1CCNCC1)=O.C([N:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH2:27][CH2:26]1)=O.[ClH:38]>C(Cl)Cl>[ClH:38].[CH:32]1([CH2:31][N:28]2[CH2:27][CH2:26][NH:25][CH2:30][CH2:29]2)[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 821911-PiperazinecarboxaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 225914231-Formyl-4-cyclohexylmethylpiperazine

生成物 1

HCID 225913861-(Cyclohexylmethyl)piperazine hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Sodium triacetoxyborohydride (10.51 g) was added to a methylene chloride (50 ml) solution containing N-formylpiperazine (5.08 g) and cyclohexanecarboxyaldehyde (7.50 g) under ice-cooling, and the mixture was stirred at room temperature for 18 hours to undergo reaction, thereby obtaining 1-formyl-4-cyclohexylmethylpiperazine, which was then acid-treated with hydrochloric acid to obtain 1-(cyclohexylmethyl)piperazine.hydrochloride.

後処理

  1. temperaturecooling
  2. customreaction

出典と根拠

ORDレコード
ord-297bfe60233642e4b473882bdbf3e196
出典データセット
uspto-grants-2005_02
特許番号
US06849622B2

関連ノート

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