2-(4-Benzyloxy-2-methoxymethoxyphenyl)ethylamine → 4-(2-Aminoethyl)-3-methoxymethoxyphenol
反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][NH2:17])=[C:11]([O:18][CH2:19][O:20][CH3:21])[CH:10]=1)C1C=CC=CC=1>[Pd].C(O)C>[NH2:17][CH2:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]=1[O:18][CH2:19][O:20][CH3:21]参加物
4
実験手順
A mixture of 18.00 g of 2-(4-benzyloxy-2-methoxymethoxyphenyl)ethylamine, 3.6 g of 10% palladium on carbon (Degussa Inc.: E101 NE/W) and 230 mL of ethanol was stirred under a hydrogen atmosphere at room temperature for 1 hour. After the catalyst was filtered off through a diatomaceous earth, the filtrate was concentrated under reduced pressure to give 12.65 g of 4-(2-aminoethyl)-3-methoxymethoxyphenol as a colorless solid.
後処理
- filtrationAfter the catalyst was filtered off through a diatomaceous earth
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-528a28312f6c48da918d6d4b5e7335f8
- 出典データセット
- uspto-grants-2009_07
- 特許番号
- US07563822B2
反応ノート
読み込み中…