Tetrahydrofuran → HCID 53718407、化合物

HRID 2295735ノート

反応式

HRID 2295735 の反応式
O1CCCC1.Cl.[NH2:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[N:11]=[C:10]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:9]=1.[CH3:28][C:29](=[CH:33][CH3:34])[C:30](Cl)=[O:31]>C(N(CC)CC)C>[NH2:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=2)[N:11]=[C:10]([N:22]2[CH2:27][CH2:26][N:25]([C:30](=[O:31])[C:29]([CH3:28])=[CH:33][CH3:34])[CH2:24][CH2:23]2)[N:9]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 30157932-Methylbut-2-enoyl chlorideHCID 204738332-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride

生成物 1

HCID 53718407HCID 53718407、化合物収率 47.4%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

To 20 ml of tetrahydrofuran were added 2.4 g of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline hydrochloride and 2.6 g of triethylamine, after which the mixture was stirred for 20 minutes. There was then added 0.7 g of 2,3-dimethylacryloyl chloride, after which the mixture was stirred at room temperature for 12 hours. The crystals which were produced were collected by filtration, washed with water and recrystallized from ethanol, to give 1.04 g of the desired Compound No. 3 in the form of pale yellow prisms melting at 219.5°-221.5° C.

後処理

  1. stirringafter which the mixture was stirred at room temperature for 12 hours
  2. customThe crystals which were produced
  3. filtrationwere collected by filtration
  4. washwashed with water
  5. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-69487d0f1ece4a14be25c892c599fac4
出典データセット
uspto-grants-1984_01
特許番号
US04426382

反応ノート

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