Sodium Iodide → Iodomethyl 3-methylbutyl carbonate
反応式
[C:1](=[O:11])([O:5][CH2:6][CH2:7][CH:8]([CH3:10])[CH3:9])[O:2][CH2:3]Cl.[I-:12].[Na+]>CC(C)=O>[C:1](=[O:11])([O:5][CH2:6][CH2:7][CH:8]([CH3:10])[CH3:9])[O:2][CH2:3][I:12]参加物
4
実験手順
Chloromethyl isopentyl carbonate (4.2 g) was dissolved in dry acetone (25 ml) and anhydrous sodium iodide (6.0 g) was added to it. The reaction mixture was stirred at room temperature protected from light for 6 hours. The acetone was evaporated off. The residue was taken in water (50 ml) and extracted with ether. The ether extract was washed successively with aqueous sodium bisulfite, water and brine and dried over sodium sulfate. Evaporation of ether gave a light-yellow oil of product weighing 6.1 g NMR (CDCl3)δ 0.96 (6H, d, J=5 Hz, (CH3)2), 1.63 (3H, m, CH2CH), 4.26 (2H, t, J=7 Hz, OCH2) and 5.96 (2H, s, CH2I).
後処理
- customThe acetone was evaporated off
- extractionextracted with ether
- extractionThe ether extract
- washwas washed successively with aqueous sodium bisulfite, water and brine
- dry with materialdried over sodium sulfate
- customEvaporation of ether
- customgave a light-yellow oil of product
出典と根拠
- ORDレコード
- ord-6d4ce1e7e36e47f6956d09160b57dba4
- 出典データセット
- uspto-grants-1984_01
- 特許番号
- US04426391
反応ノート
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