Ethanol → 3-(2-Amino-ethyl)-5-bromo-1H-indole-2-carboxylic acid

HRID 2296242

反応式

HRID 2296242 の反応式
Cl.C([O:4][C:5]([C:7]1[NH:18][C:17]2[C:12](=[CH:13][C:14]([Br:19])=[CH:15][CH:16]=2)[C:8]=1[CH2:9][CH2:10][NH2:11])=[O:6])C.C(O)C.[OH-].[Na+]>C(O)(=O)C>[Br:19][C:14]1[CH:13]=[C:12]2[C:17]([NH:18][C:7]([C:5]([OH:6])=[O:4])=[C:8]2[CH2:9][CH2:10][NH2:11])=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 13241174Ethyl-5-bromo-tryptamine-2-carboxylate hydrochloride

生成物 1

HCID 7627893-(2-Amino-ethyl)-5-bromo-1H-indole-2-carboxylic acid収率 91%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

1.00 g. (2.87 mmoles) of ethyl-5-bromo-tryptamine-2-carboxylate hydrochloride are boiled for 2 hours in a mixture of 10 ml. of ethanol and 10 ml. of 4 n aqueous sodium hydroxide solution. The mixture is cooled with ice, acidified to pH 6 with glacial acetic acid, and the separated crystals are collected by filtration. 0.75 g. (91%) of 5-bromo-tryptamine-2-carboxylic acid are obtained; m.p.; 248°-249° C.

後処理

  1. temperatureThe mixture is cooled with ice
  2. filtrationthe separated crystals are collected by filtration

出典と根拠

ORDレコード
ord-86a51e9d8a51439394de67025f3e5cbb
出典データセット
uspto-grants-1984_01
特許番号
US04428877

関連ノート

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