Ethyl pyrazinecarboxylate → Ethyl 1,4,5,6-tetrahydropyrazine-2-carboxylate
反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]>[H][H].[OH-].[OH-].[Pd+2]>[NH:1]1[CH2:6][CH2:5][NH:4][CH:3]=[C:2]1[C:7]([O:9][CH2:10][CH3:11])=[O:8]参加物
4
実験手順
A solution of ethyl pyrazine-2-carboxylate (60 g) in ETOH (500 ml) was subjected to catalytic reduction using palladium hydroxide on carbon (5.0 g), in hydrogen at 3 atm for 4 hours. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to give 62.8 g of ethyl 1,4,5,6-tetrahydropyrazine-2-carboxylate as an oil.
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-aaa482584e4040f7accc379e3ad34645
- 出典データセット
- uspto-grants-2002_12
- 特許番号
- US06489324B2
反応ノート
読み込み中…