Sodium Hydroxide → 2,2'-{Propane-2,2-diylbis[(4,1-phenylene)oxy]}diacetic acid

HRID 2296895ノート

反応式

HRID 2296895 の反応式
C([O:3][C:4]([CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([C:17]2[CH:29]=[CH:28][C:20]([O:21][CH2:22][C:23]([O:25]CC)=[O:24])=[CH:19][CH:18]=2)([CH3:16])[CH3:15])=[CH:10][CH:9]=1)=[O:5])C.[OH-].[Na+]>CO>[C:23]([CH2:22][O:21][C:20]1[CH:19]=[CH:18][C:17]([C:14]([C:11]2[CH:10]=[CH:9][C:8]([O:7][CH2:6][C:4]([OH:5])=[O:3])=[CH:13][CH:12]=2)([CH3:16])[CH3:15])=[CH:29][CH:28]=1)([OH:25])=[O:24]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 12359780HCID 12359780、化合物

生成物 1

HCID 123597752,2'-{Propane-2,2-diylbis[(4,1-phenylene)oxy]}diacetic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

6.7 g of ethyl 4-[1-(4-ethoxycarbonylmethoxyphenyl)-1-methylethyl]phenoxyacetate are dissolved in 20 ml of methanol, and 16.7 g of 10% strength sodium hydroxide solution are added. The mixture is heated to boiling under reflux for 3 hours, after which it is cooled down and the methanol is then distilled off on a rotary evaporator. The residue is diluted with water and acidified to pH 2 with 2 N HCl; the colorless precipitate is then filtered off with suction, washed with water and dried in vacuo over calcium chloride. 5.5 g of the title compound, having a m.p. of 177-179° C., are obtained.

後処理

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. temperatureafter which it is cooled down
  4. distillationthe methanol is then distilled off on a rotary evaporator
  5. additionThe residue is diluted with water
  6. filtrationthe colorless precipitate is then filtered off with suction
  7. washwashed with water
  8. dry with materialdried in vacuo over calcium chloride
  9. customare obtained

出典と根拠

ORDレコード
ord-c02c2dc1e12c45c69cd88e7ef1676e72
出典データセット
uspto-grants-2002_12
特許番号
US06489327B1

反応ノート

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