Benzyl Isothiocyanate → 4-Benzyl-1-(thiophene-2-carbonyl)thiosemicarbazide

HRID 229757

反応式

HRID 229757 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][NH2:9])=[O:7].[CH2:10]([N:17]=[C:18]=[S:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(#N)C>[CH2:10]([NH:17][C:18]([NH:9][NH:8][C:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)=[O:7])=[S:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 2346Benzyl IsothiocyanateHCID 73098Thiophene-2-carbohydrazide

生成物 1

HCID 52606884-Benzyl-1-(thiophene-2-carbonyl)thiosemicarbazide収率 89.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a hot solution of 2-thiophencarboxylic acid hydrazide (5.0 g, 35 mmol) in acetonitrile (80 mL) was added neat benzyl isothiocyanate (4.7 mL, 35 mmol) via syringe. When the solvent started to boil, the reaction vessel was removed from the heat source and allowed to cool to room temperature. The resulting crystals were collected by vacuum filtration, washed with diethyl ether and air-dried to yield N-benzyl-2-(thien-2-ylcarbonyl)hydrazinecarbothioamide (9.11 g; 89%; (M+H)+−292.2).

後処理

  1. customthe reaction vessel was removed from the heat source
  2. filtrationThe resulting crystals were collected by vacuum filtration
  3. washwashed with diethyl ether
  4. customair-dried

出典と根拠

ORDレコード
ord-af782016dd43493eba98f290432a7005
出典データセット
uspto-grants-2009_07
特許番号
US07563905B2

関連ノート

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