Triethylamine → 2-Ethyltricyclo[3.3.1.1~3,7~]decan-2-yl prop-2-enoate

HRID 2298738ノート

反応式

HRID 2298738 の反応式
[CH2:1]([C:3]1([OH:13])[CH:10]2[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:12][CH:4]1[CH2:5]3)[CH2:9]2)[CH3:2].C(N(CC)CC)C.[C:21](Cl)(=[O:24])[CH:22]=[CH2:23]>CC(CC(C)C)=O>[C:21]([O:13][C:3]1([CH2:1][CH3:2])[CH:4]2[CH2:12][CH:8]3[CH2:7][CH:6]([CH2:11][CH:10]1[CH2:9]3)[CH2:5]2)(=[O:24])[CH:22]=[CH2:23]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 44019512-Ethyl-2-adamantanol

生成物 1

HCID 221688802-Ethyltricyclo[3.3.1.1~3,7~]decan-2-yl prop-2-enoate収率 80%

試薬・触媒・溶媒 1

HCID 7909Methyl Isobutyl Ketone溶媒

反応条件

温度
40 °C

実験手順

180 g of 2-Ethyl-2-adamantanol, 303 g of triethylamine and 500 g of methylisobutyl ketone were mixed by stirring at 40° C. While stirring, 136 g of acrylic acid chloride was added dropwise to the mixture. After completion of the dropwise addition, the mixture was stirred for three more hours. Then, extraction and distillation were conducted to obtain 2-ethyl-2-adamantyl acrylate at the yield of 80%.

後処理

  1. stirringWhile stirring
  2. additionAfter completion of the dropwise addition
  3. stirringthe mixture was stirred for three more hours
  4. extractionThen, extraction and distillation

出典と根拠

ORDレコード
ord-f978f646b1ed48bebdf242c9bf9a7a76
出典データセット
uspto-grants-2002_12
特許番号
US06495307B2

反応ノート

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