Glycerol → 1-o-t-Butyldimethylsilyl-2-o-methyl-rac-glycerol
反応式
OCC(CO)O.C([O:14][CH2:15][CH:16]([CH2:19][O:20][Si:21]([C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:23])[CH3:22])[O:17][CH3:18])C1C=CC=CC=1>[Pd].CO>[Si:21]([O:20][CH2:19][CH:16]([CH2:15][OH:14])[O:17][CH3:18])([C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:23])[CH3:22]参加物
5
実験手順
A mixture of the protected glycerol derivative Compound 41 (5.0 g, 16 mmol) and 10% palladium on activated carbon (wet Degussa type E101 NE/W) (0.43 g) in MeOH (50 mL) was evacuated using an aspirator pump and filled with hydrogen. After 2 hours, TLC analysis showed the reaction to be complete, the mixture was filtered through Celite and the filtrate was evaporated to dryness to give 1-O-t-butyldimethylsilyl-2-O-methyl-rac-glycerol (Compound 42) (99%) as a colourless oil.
後処理
- customwas evacuated
- additionfilled with hydrogen
- customthe reaction
- filtrationthe mixture was filtered through Celite
- customthe filtrate was evaporated to dryness
出典と根拠
- ORDレコード
- ord-0587585ac7be4f35997cdf8cbf16d058
- 出典データセット
- uspto-grants-2002_12
- 特許番号
- US06495532B1
反応ノート
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