Sodium Hydroxide → HCID 18378526、化合物
反応式
C([N:4]1[CH2:10][CH2:9][CH2:8][N:7]([CH3:11])[C:6]2[N:12]=[CH:13][CH:14]=[CH:15][C:5]1=2)(=O)C.[OH-].[Na+]>Cl>[CH3:11][N:7]1[CH2:8][CH2:9][CH2:10][NH:4][C:5]2[CH:15]=[CH:14][CH:13]=[N:12][C:6]1=2参加物
4
実験手順
A solution of 1-acetyl-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepine (1.7 g) in 6N hydrochloric acid (60 ml) was heated at 100° C. for 6 hours. After cooling, the mixture was basified with aqueous sodium hydroxide and extracted with ethyl acetate. The extracted organic layer was washed with brine and dried over sodium sulfate and concentrated in vacuo. The residue was washed with hexane to give 5-methyl-2,3,4,5-tetrahydro-1H-pyrido[2,3-b][1,4]diazepine (1.3 g).
後処理
- temperatureAfter cooling
- extractionextracted with ethyl acetate
- washThe extracted organic layer was washed with brine
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
- washThe residue was washed with hexane
出典と根拠
- ORDレコード
- ord-f4bd085952d848ae8b9f5ff0e20dc6a8
- 出典データセット
- uspto-grants-2002_12
- 特許番号
- US06495542B1
反応ノート
読み込み中…