Potassium Carbonate → Ethyl 3-[benzyl(2-methoxy-2-oxoethyl)amino]butanoate

HRID 2299105

反応式

HRID 2299105 の反応式
[CH2:1]([NH:8][CH:9]([CH3:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:18][C:19]([O:21][CH3:22])=[O:20].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:1]([N:8]([CH2:18][C:19]([O:21][CH3:22])=[O:20])[CH:9]([CH3:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 236384Ethyl 3-(benzylamino)butanoate

生成物 1

HCID 18379207Ethyl 3-[benzyl(2-methoxy-2-oxoethyl)amino]butanoate収率 82.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A suspension of ethyl 3-(benzylamino)butanoate (5.9 g, 26.7 mmol), methyl bromoacetate (3.0 ml, 31.7 mmol) and potassium carbonate (7.4 g, 53.5 mmol) in acetonitrile (100 ml), was stirred at room temperature for 18 hs. The reaction was filtered through celite and concentrated to give ethyl 3-[benzyl(2-methoxy-2-oxoethyl)amino]butanoate (6.45 g, 82%) as a clear oil, MS (M+H)+=294.

後処理

  1. filtrationThe reaction was filtered through celite and
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-1172e6df8a92440db103cfa3ddf1bc7d
出典データセット
uspto-grants-2002_12
特許番号
US06495565B2

関連ノート

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